Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552340 | 0.93 | CHEK2 (0.88) | CHEK2 | |
| SCHEMBL5641199 | 0.91 | CHEK2 (0.75) | CHEK2HTR2B | |
| SCHEMBL1552385 | 0.90 | CHEK2 (0.77) | CHEK2HTR2BDHODH | |
| SCHEMBL5640439 | 0.90 | CHEK2 (0.74) | CHEK2DHODH | |
| SCHEMBL5638539 | 0.87 | CHEK2 (0.77) | CHEK2 | |
| SCHEMBL1553003 | 0.84 | CHEK2 (0.87) | CHEK2 | |
| SCHEMBL5639672 | 0.84 | CHEK2 (0.74) | CHEK2 | |
| SCHEMBL5639532 | 0.84 | CHEK2 (0.77) | CHEK2 | |
| SCHEMBL5639443 | 0.82 | CHEK2 (0.76) | CHEK2 | |
| SCHEMBL1552713 | 0.82 | CHEK2 (0.70) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250427-B2 | Aryl-substituted benzimidazole and imidazopyridine ethers | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-31 | — | — | US | disclosed |
| US-20060004039-A1 | Aryl-substituted benzimidazole and imidazopyridine ethers | JANSSEN PHARMACEUTICA, N. V. (BE) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004039-A1 | Aryl-substituted benzimidazole and imidazopyridine ethers | WEE1, CDKN1A, DDB1 | CHEK2 27/4885HTR2B 3184/4885DHODH 2890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.