Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.63 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.63 |
| ▸ | LCK | P06239 | 5/20 | 0.49 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641887 | 0.86 | MAPK14 (0.68) | MAPK14HSPB1LCKCSF1REGFR | |
| SCHEMBL4703449 | 0.85 | MAPK14 (0.67) | MAPK14HSPB1LCKHTR1D | |
| SCHEMBL4700691 | 0.83 | MAPK14 (0.65) | MAPK14HSPB1LCKCSF1REGFR | |
| SCHEMBL4700588 | 0.83 | MAPK1 (0.58) | MAPK14HSPB1LCKCSF1RHTR1D | |
| SCHEMBL4701902 | 0.81 | MAPK14 (0.57) | MAPK14HSPB1LCKCSF1REGFR | |
| SCHEMBL4701504 | 0.81 | MAPK14 (0.69) | MAPK14HSPB1 | |
| SCHEMBL4702778 | 0.79 | MAPK14 (0.66) | MAPK14HSPB1 | |
| SCHEMBL5641957 | 0.79 | MAPK14 (0.66) | MAPK14HSPB1MAPK13MAPK12MAPK11 | |
| SCHEMBL4819651 | 0.79 | MAPK14 (0.74) | MAPK14HSPB1 | |
| SCHEMBL5380271 | 0.78 | MAPK14 (0.64) | MAPK14HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309800-B2 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-12-18 | — | — | US | claimed |