SCHEMBL5645192

SCHEMBL5645192

Cc1c(NC(=O)c2ccc(-c3ccc(F)cc3)cc2)ccc2cc(CN3CCC(CC(N)=O)CC3)cnc12

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.77
HTR2C P28335 6/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5647531 0.92 MCHR1 (0.74) MCHR1HTR2C
SCHEMBL5650442 0.91 MCHR1 (0.76) MCHR1HTR2C
SCHEMBL5647586 0.91 MCHR1 (0.75) MCHR1HTR2C
SCHEMBL5649492 0.90 MCHR1 (0.74) MCHR1HTR2C
SCHEMBL5647984 0.89 MCHR1 (0.73) MCHR1HTR2C
SCHEMBL5647888 0.89 MCHR1 (0.78) MCHR1HTR2C
SCHEMBL5649707 0.87 MCHR1 (0.96) MCHR1HTR2C
SCHEMBL5646099 0.87 MCHR1 (1.00) MCHR1HTR2C
SCHEMBL5649203 0.87 MCHR1 (0.98) MCHR1HTR2C
SCHEMBL5651993 0.87 MCHR1 (0.98) MCHR1HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183415-B2 Quinoline compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-27 US disclosed
US-7183415-B2 Quinoline compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-27 US disclosed
US-7183415-B2 Quinoline compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-27 US disclosed