Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.70 |
| ▸ | GAK | O14976 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 12/20 | 0.67 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648577 | 0.92 | KDR (0.64) | EGFRGAKKDR | |
| SCHEMBL5066448 | 0.90 | KDR (0.66) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL5651397 | 0.90 | KDR (0.62) | EGFRGAKKDRSRC | |
| SCHEMBL5652242 | 0.89 | KDR (0.69) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL5652007 | 0.88 | KDR (0.68) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL5649306 | 0.88 | KDR (0.61) | EGFRGAKKDRSRC | |
| SCHEMBL5649229 | 0.88 | KDR (0.65) | EGFRGAKKDR | |
| SCHEMBL5651072 | 0.86 | KDR (0.59) | EGFRGAKKDR | |
| SCHEMBL5650446 | 0.86 | KDR (0.65) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL5646361 | 0.86 | KDR (0.65) | EGFRGAKKDRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | EGFR 439/4885GAK 123/4885KDR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.