Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.45 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649268 | 0.90 | F2 (0.44) | F2PRSS1 | |
| SCHEMBL5648186 | 0.87 | KLKB1 (0.45) | KLKB1F2PRSS1 | |
| SCHEMBL5652219 | 0.85 | KLKB1 (0.49) | KLKB1F2PRSS1 | |
| SCHEMBL5646766 | 0.83 | F2 (0.55) | KLKB1F2PRSS1 | |
| SCHEMBL5647756 | 0.82 | F2 (0.43) | F2 | |
| SCHEMBL5649574 | 0.82 | F2 (0.43) | F2PRSS1 | |
| SCHEMBL5968782 | 0.82 | KDM4E (0.39) | F2 | |
| SCHEMBL5651422 | 0.81 | F2 (0.50) | KLKB1F2PRSS1 | |
| SCHEMBL5650377 | 0.81 | F2 (0.42) | KLKB1F2PRSS1 | |
| SCHEMBL5651604 | 0.81 | KLKB1 (0.43) | KLKB1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161643-A1 | Pyridin-2-one compounds useful as inhibitors of thrombin | PLG, F2, PLAT | KLKB1 113/4885F2 2/4885PRSS1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.