Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.67 |
| ▸ | EGFR | P00533 | 10/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647590 | 0.93 | EGFR (0.65) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5650383 | 0.93 | EGFR (0.62) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5647373 | 0.93 | EGFR (0.65) | KDREGFRSRCERBB2 | |
| SCHEMBL5648952 | 0.91 | EGFR (0.61) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5651221 | 0.91 | EGFR (0.58) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5650838 | 0.90 | KDR (0.68) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5652609 | 0.89 | KDR (0.64) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5649674 | 0.89 | KDR (0.64) | KDREGFREPHA2EPHB4SRC | |
| SCHEMBL5652274 | 0.88 | KDR (0.63) | KDREGFR | |
| SCHEMBL5652647 | 0.87 | KDR (0.65) | KDREGFREPHA2EPHB4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | WYETH (US) | 2007-12-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299092-A1 | Quinone Substituted Quinazoline and Quinoline Kinase Inhibitors | KDR, FLT1, FLT4 | KDR 1/4885EGFR 439/4885EPHA2 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.