Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063757 | 0.85 | KMT2A (0.60) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL29151219 | 0.83 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL1942220 | 0.81 | KCNQ3 (0.55) | SMN1; SMN2MAPTMEN1KMT2AKCNQ3 | |
| SCHEMBL5648961 | 0.78 | CYP1A2 (0.54) | RAB9AALDH1A1MEN1KMT2AKCNQ3 | |
| SCHEMBL31241045 | 0.78 | KCNQ3 (0.53) | RAB9ALMNAMEN1KMT2AKCNQ3 | |
| SCHEMBL21616930 | 0.77 | KDR (0.63) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7142315 | 0.77 | KMT2A (0.71) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL8711539 | 0.77 | KMT2A (0.71) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL5652401 | 0.77 | HDAC3 (0.43) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL28221070 | 0.75 | MEN1 (0.72) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |