Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573614 | 0.88 | GRM5 (0.78) | GRM5 | |
| SCHEMBL5652544 | 0.88 | GRM5 (0.78) | GRM5 | |
| SCHEMBL14573624 | 0.85 | GRM5 (1.00) | GRM5 | |
| SCHEMBL5654493 | 0.85 | GRM5 (0.74) | GRM5 | |
| SCHEMBL2758340 | 0.85 | GRM5 (1.00) | GRM5 | |
| SCHEMBL23048378 | 0.85 | GRM5 (0.74) | GRM5 | |
| SCHEMBL15694393 | 0.85 | GRM5 (0.74) | GRM5 | |
| SCHEMBL5651051 | 0.83 | GRM5 (0.71) | GRM5 | |
| SCHEMBL15291270 | 0.83 | GRM5 (0.71) | GRM5 | |
| SCHEMBL2758326 | 0.83 | GRM5 (0.71) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060618-A1 | Alkyne derivatives as tracers for metabotropic glutamate receptor binding | MERCK & CO., INC. (US) | 2007-03-15 | — | — | US | disclosed |
| US-20070060618-A1 | Alkyne derivatives as tracers for metabotropic glutamate receptor binding | MERCK & CO., INC. (US) | 2007-03-15 | — | — | US | disclosed |
| EP-1556142-A4 | ALKYNE DERIVATIVES AS TRACERS FOR METABOTROPIC GLUTAMATE RECEPTOR BINDING | MERCK & CO INC (US) | 2006-11-08 | — | — | EP | disclosed |
| EP-1556142-A2 | ALKYNE DERIVATIVES AS TRACERS FOR METABOTROPIC GLUTAMATE RECEPTOR BINDING | Merck & Co., Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004038374-A2 | ALKYNE DERIVATIVES AS TRACERS FOR METABOTROPIC GLUTAMATE RECEPTOR BINDING | MERCK & CO., INC. (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060618-A1 | Alkyne derivatives as tracers for metabotropic glutamate receptor binding | GRM5, GRM3, GRIK5 | GRM5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.