Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653786 | 0.93 | HDAC1 (0.47) | HDAC1PTGER4SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5654551 | 0.91 | HDAC1 (0.47) | HDAC1PTGER4SIRT5FOLH1 | |
| SCHEMBL5653748 | 0.91 | HDAC1 (0.48) | HDAC1PTGER4SIRT5SMN1; SMN2NPC1 | |
| SCHEMBL5654868 | 0.89 | HDAC1 (0.46) | HDAC1PTGER4SIRT5FOLH1 | |
| SCHEMBL5655924 | 0.88 | HDAC1 (0.47) | HDAC1PTGER4SIRT5FOLH1 | |
| SCHEMBL5655045 | 0.88 | PTGER4 (0.52) | HDAC1PTGER4SIRT5FOLH1 | |
| SCHEMBL5654879 | 0.87 | HDAC1 (0.49) | HDAC1PTGER4SIRT5 | |
| SCHEMBL5654619 | 0.86 | PTGER4 (0.48) | HDAC1PTGER4SIRT5FOLH1 | |
| SCHEMBL5652787 | 0.85 | HDAC1 (0.46) | HDAC1PTGER4SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5652247 | 0.85 | HDAC1 (0.49) | HDAC1PTGER4SIRT5FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142638-A1 | Ornithine derivatives as prostaglandin e2 agonists or antagonists | ASTELLAS PHARMA INC. (JP) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142638-A1 | Ornithine derivatives as prostaglandin e2 agonists or antagonists | PTGER4, OXER1, RXFP4 | HDAC1 1416/4885PTGER4 1/4885SIRT5 1504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.