Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | CASP3 | P42574 | 6/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | CASP9 | P55211 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 5/20 | 0.59 |
| ▸ | CES1 | P23141 | 3/20 | 0.59 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30555218 | 1.00 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL458636 | 0.81 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL2260735 | 0.81 | CA1 (1.00) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL5893648 | 0.81 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| Potassium Ion SCHEMBL5858452 | 0.81 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL454611 | 0.81 | CA12 (0.69) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL31388442 | 0.80 | BRD4 (0.54) | CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL5184450 | 0.80 | CA12 (0.67) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL454612 | 0.80 | CA12 (0.67) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL5858448 | 0.80 | CA12 (0.67) | CA12CA1CA2CA9CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655518-A | Isatin derivative and preparation method and application thereof | 东南大学 | 2023-08-29 | — | — | CN | claimed |
| CN-116655518-A | Isatin derivative and preparation method and application thereof | 东南大学 | 2023-08-29 | — | — | CN | disclosed |
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| EP-2367816-B1 | ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS | IMP INNOVATIONS LTD (GB) | 2016-11-09 | — | — | EP | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-8961930-B2 | Isatin derivatives for use as in vivo imaging agents | IMPERIAL INNOVATIONS LIMITED (GB) | 2015-02-24 | — | — | US | disclosed |
| US-6514992-B1 | Excessive or inappropriate apoptosis in the neuronal cells occurs in Alzheimer disease and ischemia, T cells in HIV and cardiac myocytes during infarction/reperfusion; caspases inhibit apoptosis | SMITHKLINE BEECHAM CORPORATION | 2003-02-04 | — | — | US | disclosed |
| EP-1001933-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6403792-B1 | INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |
| EP-1087663-A2 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001933-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999065451-A2 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |
| WO-1999006367-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |
| WO-1995013807-A1 | INDOLO[2,1-b]QUINAZOLINE-6,12-DIONE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | PATHOGENESIS CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |