Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.63 |
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650637 | 0.91 | AURKA (0.72) | AURKAKDREGFRAURKBIRAK4 | |
| SCHEMBL5651656 | 0.87 | EGFR (0.65) | AURKAKDREGFRAURKBIRAK4 | |
| SCHEMBL5651175 | 0.86 | AURKA (0.60) | AURKAKDREGFRAURKB | |
| SCHEMBL5652035 | 0.86 | AURKA (0.68) | AURKAKDREGFRAURKB | |
| SCHEMBL5649428 | 0.84 | AURKA (0.75) | AURKAKDREGFRAURKBIRAK4 | |
| SCHEMBL5023489 | 0.83 | AURKA (0.78) | AURKAKDREGFRAURKBHDAC3 | |
| SCHEMBL3525693 | 0.81 | AURKB (0.84) | AURKAKDREGFRAURKBIRAK4 | |
| SCHEMBL10152557 | 0.81 | AURKA (0.69) | AURKAKDREGFRAURKBIRAK4 | |
| SCHEMBL5016557 | 0.80 | AURKA (0.74) | AURKAKDREGFRAURKBHDAC3 | |
| Hydrochloric Acid SCHEMBL2063014 | 0.80 | AURKA (0.69) | AURKAKDREGFRAURKBIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |