Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026708 | 0.86 | CYP3A4 (0.51) | IDO1CYP3A4MAOBDHFRGRM5 | |
| SCHEMBL5652119 | 0.85 | MAOB (0.47) | KDM4EIDO1POLBMEN1KMT2A | |
| SCHEMBL5649177 | 0.81 | NPC1 (0.59) | KDM4EIDO1POLBALDH1A1RAB9A | |
| SCHEMBL5650279 | 0.80 | NPC1 (0.44) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL224083 | 0.77 | MAOB (0.56) | KDM4EIDO1MEN1KMT2ARAB9A | |
| SCHEMBL29561621 | 0.77 | MAOB (0.56) | KDM4EIDO1MEN1KMT2ARAB9A | |
| SCHEMBL11183025 | 0.77 | KDM4E (0.62) | KDM4EIDO1POLBMEN1KMT2A | |
| SCHEMBL7082856 | 0.76 | CYP19A1 (0.42) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL25382254 | 0.75 | AGXT (0.46) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL3365264 | 0.75 | MEN1 (0.60) | KDM4EIDO1MEN1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |