Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.73 |
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473767 | 0.85 | ABCG2 (1.00) | ABCG2EGFRKDRRETCLK1 | |
| Hydrochloric Acid SCHEMBL5478012 | 0.84 | ABCG2 (0.98) | ABCG2EGFRKDRRETCLK1 | |
| SCHEMBL5650807 | 0.84 | SRC (0.65) | ABCG2EGFRMAPTKDRRET | |
| SCHEMBL27748217 | 0.81 | ABCG2 (0.72) | ABCG2EGFRMAPTALDH1A1HTT | |
| SCHEMBL371602 | 0.80 | ABCG2 (0.71) | ABCG2EGFRMAPTALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL6786294 | 0.80 | ABCG2 (0.71) | ABCG2EGFRMAPTALDH1A1HTT | |
| SCHEMBL5654317 | 0.80 | EGFR (0.65) | ABCG2EGFRKDRRETCLK1 | |
| SCHEMBL2099212 | 0.80 | ABCG2 (1.00) | ABCG2EGFRMAPTALDH1A1KDR | |
| Hydrochloric Acid SCHEMBL5468096 | 0.79 | ABCG2 (0.98) | ABCG2EGFRMAPTALDH1A1KDR | |
| SCHEMBL31554531 | 0.78 | ABCG2 (0.68) | ABCG2EGFRKDRRETCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |