Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 17/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5524824 | 0.90 | CASR (0.93) | CASRHTTCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5515067 | 0.90 | CASR (0.93) | CASRHTTCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5517787 | 0.90 | CASR (0.93) | CASRHTTCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5513201 | 0.90 | CASR (0.93) | CASRHTTCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL14522258 | 0.87 | CASR (0.73) | CASRHTT | |
| SCHEMBL5519297 | 0.86 | CASR (1.00) | CASRHTTCYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5516485 | 0.80 | CASR (0.82) | CASRCYP2D6SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL5521295 | 0.79 | CASR (0.80) | CASRCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5511591 | 0.78 | CASR (0.74) | CASRCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5524136 | 0.76 | CASR (0.76) | CASRCYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249702-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249702-A1 | CALCILYTIC COMPOUNDS | CALCR, CASR, ORAI1 | CASR 2/4885HTT 3839/4885GHSR 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.