Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.67 |
| ▸ | PPARA | Q07869 | 8/20 | 0.67 |
| ▸ | PPARG | P37231 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801971 | 0.87 | PPARD (0.52) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL5655928 | 0.83 | MAPT (0.56) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL27602733 | 0.81 | PPARG (0.45) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL5487763 | 0.81 | PPARD (0.68) | PPARDPPARAPPARGMAPTNPC1 | |
| SCHEMBL2166922 | 0.81 | PPARD (0.69) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL27630333 | 0.81 | FFAR1 (0.64) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL5656255 | 0.80 | PPARD (1.00) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL27650470 | 0.80 | PPARD (0.69) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL3374725 | 0.80 | MAPT (0.60) | PPARDPPARAPPARGMAPTFFAR1 | |
| SCHEMBL27630404 | 0.79 | PPARD (0.55) | PPARDPPARAPPARGMAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1507442-A | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors | — | 2004-06-23 | — | — | CN | claimed |
| US-7196107-B2 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196107-B2 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196107-B2 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1343772-B1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LTD (GB) | 2006-05-31 | — | — | EP | disclosed |
| CN-1507442-A | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors | — | 2004-06-23 | — | — | CN | disclosed |
| US-20040102493-A1 | Thia-and oxazoles and their use as ppars activators | SMITHKLINE BEECHAM CORPORATION | 2004-05-27 | — | — | US | disclosed |
| EP-1343772-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050048-A1 | THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102493-A1 | Thia-and oxazoles and their use as ppars activators | PPARA, PPARG, NCOA1 | PPARD 7/4885PPARA 1/4885PPARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.