Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.68 |
| ▸ | CHUK | O15111 | 6/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14589275 | 0.89 | IKBKB (0.67) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589292 | 0.88 | IKBKB (0.65) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589296 | 0.87 | IKBKB (0.69) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589286 | 0.87 | IKBKB (0.73) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5659239 | 0.87 | IKBKB (0.68) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL5658686 | 0.86 | IKBKB (0.80) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589274 | 0.85 | IKBKB (0.71) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589267 | 0.85 | IKBKB (0.66) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589261 | 0.85 | IKBKB (0.70) | IKBKBCHUKJAK2TYK2CDK2 | |
| SCHEMBL14589282 | 0.84 | IKBKB (0.64) | IKBKBCHUKJAK2TYK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176214-B2 | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176214-B2 | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176214-B2 | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-13 | — | — | US | disclosed |