Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.89 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229067 | 0.94 | GSK3B (1.00) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5660695 | 0.91 | GSK3B (0.73) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5656666 | 0.91 | GSK3B (0.73) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5658704 | 0.87 | GSK3B (0.67) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5659768 | 0.85 | GSK3B (0.64) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5656429 | 0.85 | GSK3B (0.64) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5231880 | 0.84 | GSK3B (0.81) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4847269 | 0.84 | GSK3B (0.81) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5659289 | 0.84 | GSK3B (0.63) | GSK3BMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5657921 | 0.84 | GSK3B (0.62) | GSK3BPOLBKMT2AROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |