Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 8/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666281 | 0.99 | SERPINE1 (0.46) | SERPINE1PTPN1PTPN2PTPN11POLB | |
| SCHEMBL5665855 | 0.98 | SERPINE1 (0.45) | SERPINE1PTPN1PTPN2PTPN11POLB | |
| SCHEMBL5908258 | 0.97 | SERPINE1 (0.46) | SERPINE1PTPN1PTPN2PTPN11POLB | |
| SCHEMBL29935518 | 0.95 | SERPINE1 (0.50) | SERPINE1PTPN1PTPN2PTPN11POLB | |
| SCHEMBL391922 | 0.90 | SERPINE1 (0.57) | SERPINE1PTPN1PTPN2PTPN11TYR | |
| SCHEMBL28031026 | 0.90 | SERPINE1 (0.57) | SERPINE1PTPN1PTPN2PTPN11TYR | |
| Water SCHEMBL23067557 | 0.89 | SERPINE1 (0.56) | SERPINE1PTPN1PTPN2PTPN11TYR | |
| SCHEMBL9646034 | 0.82 | SERPINE1 (0.46) | SERPINE1PTPN1PTPN2PTPN11POLB | |
| SCHEMBL20530411 | 0.79 | SERPINE1 (0.57) | SERPINE1PTPN1PTPN2PTPN11L3MBTL1 | |
| SCHEMBL28064168 | 0.79 | SERPINE1 (0.57) | SERPINE1PTPN1PTPN2PTPN11L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545554-A4 | METHODS AND COMPOSITIONS FOR TREATING DIABETES MELLITIS | UNIV OHIO (US) | 2006-06-14 | — | — | EP | claimed |
| US-20060058243-A1 | Methods and compositions for treating diabetes mellitis | OHIO UNIVERSITY | 2006-03-16 | — | — | US | claimed |
| EP-1545554-A1 | METHODS AND COMPOSITIONS FOR TREATING DIABETES MELLITIS | Ohio University (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004009094-A1 | METHODS AND COMPOSITIONS FOR TREATING DIABETES MELLITIS | OHIO UNIVERSITY (US) | 2004-01-29 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058243-A1 | Methods and compositions for treating diabetes mellitis | IAPP, GCG, MTPN | SERPINE1 196/4885PTPN1 1169/4885PTPN2 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.