Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 9/20 | 0.54 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.50 |
| ▸ | CALCA | P06881 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272342 | 1.00 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1KMT2A | |
| SCHEMBL3590576 | 0.99 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1KMT2A | |
| SCHEMBL3592002 | 0.99 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1KMT2A | |
| SCHEMBL3590594 | 0.99 | CALCRL (0.54) | CALCRLRAMP1CALCARIPK1KMT2A | |
| Lithium Ion SCHEMBL1272339 | 0.87 | CALCRL (0.51) | CALCRLRAMP1CALCARIPK1KMT2A | |
| SCHEMBL1274595 | 0.86 | CALCRL (0.46) | CALCRLRAMP1CALCAKMT2AMEN1 | |
| SCHEMBL17022981 | 0.84 | CALCRL (0.42) | CALCRLRAMP1CALCARIPK1 | |
| SCHEMBL12950639 | 0.83 | CALCRL (0.48) | CALCRLRAMP1CALCA | |
| SCHEMBL12950641 | 0.83 | CALCRL (0.48) | CALCRLRAMP1CALCA | |
| SCHEMBL3597448 | 0.83 | CALCRL (0.46) | CALCRLRAMP1CALCAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265225-A1 | Substituted monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME LLC | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265225-A1 | Substituted monocyclic CGRP receptor antagonists | QRFPR, CALCRL, EDNRB | CALCRL 2/4885RAMP1 70/4885CALCA 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.