Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395510 | 1.00 | ELANE (0.74) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1245162 | 0.95 | ELANE (0.79) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1764354 | 0.90 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872750 | 0.90 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL3482734 | 0.90 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14899953 | 0.89 | ELANE (0.90) | ELANECYP2C9CYP3A4 | |
| SCHEMBL6025373 | 0.88 | ELANE (0.74) | ELANECYP2C9CYP3A4 | |
| SCHEMBL394959 | 0.88 | ELANE (0.74) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1155480 | 0.87 | ELANE (0.63) | ELANECYP2C9 | |
| SCHEMBL4317225 | 0.87 | ELANE (0.82) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730121-A2 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | Bayer HealthCare AG (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005082863-A2 | 1,4 DIARYL-DIHYDROPYRIMIDIN-2 ONES AND THEIR USE AS A HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-09-09 | — | — | WO | disclosed |