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Nitric Acid

Nitric Acid

SCHEMBL5674307

C=NN(CCOc1cc(C)cc(OS(=O)(=O)c2cccc(Br)c2)c1)C(=N)N.O=[N+]([O-])O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ERG11

The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ F2 P00734 20/20 0.48
▸ CTRC Q99895 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitric Acid SCHEMBL5673470 0.92 F2 (0.54) F2CTRC
Nitric Acid SCHEMBL5676163 0.90 F2 (0.48) F2CTRC
Nitric Acid SCHEMBL5676027 0.88 F2 (0.46) F2
Nitric Acid SCHEMBL5674071 0.85 F2 (0.46) F2CTRC
Nitric Acid SCHEMBL5674586 0.83 F2 (0.57) F2CTRC
Nitric Acid SCHEMBL5675170 0.83 F2 (0.56) F2CTRC
Nitric Acid SCHEMBL5674333 0.82 F2 (0.43) F2CTRC
Nitric Acid SCHEMBL8481464 0.81 F2 (0.49) F2CTRC
Nitric Acid SCHEMBL5674101 0.80 F2 (0.57) F2CTRC
Nitric Acid SCHEMBL5674534 0.80 F2 (0.50) F2CTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906091-B1 AMIDINOHYDRAZONES AS PROTEASE INHIBITORS ORTHO MCNEIL PHARM INC (US) 2006-10-04 — — EP disclosed
EP-0906091-A4 AMIDINOHYDRAZONES AS PROTEASE INHIBITORS DIMENSIONAL PHARM INC (US) 2004-07-21 — — EP disclosed
EP-0906091-A1 AMIDINOHYDRAZONES AS PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1999-04-07 — — EP disclosed
WO-1997036580-A1 AMIDINOHYDRAZONES AS PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1997-10-09 — — WO disclosed