Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 6/20 | 0.46 |
| ▸ | MAOB | P27338 | 6/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243457 | 0.89 | KDM4E (0.54) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL4849793 | 0.88 | KDM4E (0.44) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL10577512 | 0.85 | MEN1 (0.51) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL10574409 | 0.85 | MEN1 (0.51) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL1243316 | 0.85 | KDM4E (0.54) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL8284440 | 0.77 | MEN1 (0.69) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL30390377 | 0.76 | KDM4E (0.58) | KMT2AKDM4EHSD17B1CYP2D6ACHE | |
| SCHEMBL6336267 | 0.76 | KDM4E (0.58) | KMT2AKDM4EHSD17B1CYP2D6ACHE | |
| SCHEMBL3454654 | 0.74 | MEN1 (0.73) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL25271915 | 0.73 | KDM4E (0.42) | MEN1MAPK1KMT2ANPSR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115780-B2 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same | SANOFI-AVENTIS (FR) | 2006-10-03 | — | — | US | disclosed |
| US-20050054641-A1 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same | SANOFI-AVENTIS (FR) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054641-A1 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same | ALK, CHRM4, CHRM2 | MEN1 1820/4885MAPK1 4154/4885KMT2A 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.