Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | CA12 | O43570 | 11/20 | 0.44 |
| ▸ | CA1 | P00915 | 11/20 | 0.44 |
| ▸ | CA2 | P00918 | 11/20 | 0.44 |
| ▸ | CA9 | Q16790 | 11/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20581575 | 1.00 | MAPT (0.67) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL23855305 | 1.00 | MAPT (0.67) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL29477379 | 1.00 | MAPT (0.67) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL22107791 | 0.96 | MAPT (0.62) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL27951344 | 0.91 | MAPT (0.64) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL30163231 | 0.91 | MAPT (0.64) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL28687895 | 0.91 | MAPT (0.56) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL15659417 | 0.90 | MAPT (0.62) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL15659416 | 0.90 | MAPT (0.62) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL19304981 | 0.89 | MAPT (0.61) | MAPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521761-B1 | TREATMENT OF CONGENITAL DISORDERS OF GLYCOSYLATION (CDG) USING MANNOSE | MARQUARDT THORSTEN (DE) | 2006-01-11 | — | — | EP | disclosed |
| EP-1521761-A2 | TREATMENT OF CONGENITAL DISORDERS OF GLYCOSYLATION (CDG) USING MANNOSE | Marquardt, Thorsten (DE) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003104247-A2 | TREATMENT OF CONGENITAL DISORDERS OF GLYCOSYLATION (CDG) USING MANNOSE | SHS GESELLSCHAFT FÜR KLINISCHE ERNÄHRUNG MBH (DE) | 2003-12-18 | — | — | WO | disclosed |