Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 20/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380004 | 0.92 | CHEK2 (0.64) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5680477 | 0.84 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL20982670 | 0.81 | CHEK2 (0.86) | CHEK2 | |
| SCHEMBL3922206 | 0.81 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL3917268 | 0.81 | CHEK2 (0.84) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL1378686 | 0.80 | CHEK2 (0.71) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL6643076 | 0.79 | CHEK2 (0.80) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5680091 | 0.79 | CHEK2 (1.00) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL5178371 | 0.78 | CHEK2 (0.48) | CHEK2MEN1THRBKMT2A | |
| SCHEMBL1379622 | 0.78 | CHEK2 (0.83) | CHEK2MEN1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004093873-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-11-04 | — | — | WO | disclosed |