Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379568 | 0.91 | CHEK2 (0.83) | CHEK2 | |
| SCHEMBL5679988 | 0.90 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5677625 | 0.86 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL20982670 | 0.86 | CHEK2 (0.86) | CHEK2 | |
| SCHEMBL5677658 | 0.85 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL1380924 | 0.84 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5680477 | 0.84 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL1383161 | 0.84 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5680006 | 0.83 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL2243148 | 0.82 | CHEK2 (0.80) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004093873-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-11-04 | — | — | WO | disclosed |