SCHEMBL5679356

SCHEMBL5679356

O=C(O)c1ccc(N2CC[C@@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5466323 1.00 F10 (0.69) F10
SCHEMBL5374963 0.92 F10 (0.71) F10
SCHEMBL6366488 0.90 F10 (0.73) F10
SCHEMBL6362749 0.88 F10 (0.74) F10
SCHEMBL14499114 0.88 F10 (0.72) F10
SCHEMBL5460632 0.87 F10 (0.60) F10
SCHEMBL6362500 0.87 F10 (0.72) F10
SCHEMBL5459040 0.86 F10 (0.67) F10
SCHEMBL5464336 0.86 F10 (0.67) F10
SCHEMBL6365187 0.86 F10 (0.69) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633347-A1 2-PYRROLIDONE DERIVATIVES AND USE THEREOF AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2006-03-15 EP disclosed
WO-2004110434-A1 2-PYRROLIDONE DERIVATIVES AND USE THEREOF AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2004-12-23 WO disclosed