Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32680214 | 0.79 | DYRK1A (0.49) | DYRK1ADYRK1BLPAR2MTORKCNH2 | |
| SCHEMBL15246748 | 0.79 | DYRK1A (0.49) | DYRK1ADYRK1BLPAR2MTORKCNH2 | |
| SCHEMBL5681358 | 0.79 | DYRK1A (0.49) | DYRK1ADYRK1BPDE2ALPAR2MTOR | |
| SCHEMBL11783648 | 0.78 | DYRK1A (0.48) | DYRK1ADYRK1BLPAR2MTORPHGDH | |
| SCHEMBL5681137 | 0.75 | DYRK1A (0.46) | DYRK1ADYRK1BLPAR2MTORKCNH2 | |
| SCHEMBL5679513 | 0.75 | DYRK1A (0.46) | RIPK1DYRK1ADYRK1BLPAR2MTOR | |
| SCHEMBL5683328 | 0.75 | NPY5R (0.48) | PDE2AKCNH2 | |
| SCHEMBL28406604 | 0.73 | HDAC6 (0.57) | RIPK1KCNH2 | |
| SCHEMBL16291398 | 0.73 | DYRK1A (0.80) | DYRK1ADYRK1BMTORKCNH2 | |
| SCHEMBL11789066 | 0.73 | MTOR (0.47) | DYRK1ADYRK1BLPAR2MTORPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |