Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.54 |
| ▸ | KDR | P35968 | 16/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | HCK | P08631 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210348 | 0.93 | SRC (0.61) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL3202589 | 0.87 | SRC (0.68) | SRCKDRBMPR1BGAKEPHB6 | |
| Azd-0424 SCHEMBL3202072 | 0.85 | SRC (0.73) | SRCKDRBMPR1BGAKEPHB6 | |
| Azd-0424 SCHEMBL29382167 | 0.85 | SRC (0.73) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL3671966 | 0.82 | SRC (0.68) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL3675514 | 0.82 | SRC (0.70) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL3675255 | 0.81 | SRC (0.74) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL3677564 | 0.80 | SRC (0.73) | SRCKDRBMPR1BGAKEPHB6 | |
| SCHEMBL6391139 | 0.80 | SRC (0.48) | SRCKDRPDGFRBKITFLT3 | |
| SCHEMBL3675427 | 0.80 | SRC (0.81) | SRCKDRBMPR1BGAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620104-A1 | THERAPEUTIC AGENTS COMPRISING AN ANTI-ANGIOGENIC AGENT IN COMBINATION WITH AN SRC-INHIBITOR AND THEIR THERAPEUTIC USE | Astrazeneca AB (SE) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098604-A1 | THERAPEUTIC AGENTS COMPRISING AN ANTI-ANGIOGENIC AGENT IN COMBINATION WITH AN SRC-INHIBITOR AND THEIR THERAPEUTIC USE | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | disclosed |