Iodide

Iodide

SCHEMBL5684458

I.O=C(NCCCN(CCCc1ccccc1)CCc1ccc(Cl)cc1)Nc1ccccc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 9/20 0.70
KDM4E B2RXH2 1/20 0.62
EPHX1 P07099 1/20 0.62
SMN1; SMN2 Q16637 4/20 0.62
NPC1 O15118 2/20 0.62
RAB9A P51151 2/20 0.62
KMT2A Q03164 6/20 0.59
MEN1 O00255 5/20 0.59
HTT P42858 4/20 0.59
ALDH1A1 P00352 3/20 0.59
LMNA P02545 3/20 0.59
TP53 P04637 1/20 0.59
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2C9 P11712 2/20 0.53
CYP2C19 P33261 2/20 0.53
MAPT P10636 4/20 0.52
CYP2D6 P10635 1/20 0.52
GAA P10253 1/20 0.52
CASR P41180 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL5681782 0.99 CNR1 (0.67) CNR1KDM4EEPHX1SMN1; SMN2NPC1
SCHEMBL5681199 0.95 CNR1 (0.68) CNR1KDM4EEPHX1SMN1; SMN2NPC1
Iodide SCHEMBL5681803 0.94 CNR1 (0.61) CNR1KDM4EEPHX1SMN1; SMN2NPC1
Iodide SCHEMBL5679942 0.91 CNR1 (0.62) CNR1KDM4EEPHX1SMN1; SMN2NPC1
Iodide SCHEMBL5681261 0.91 CNR1 (0.60) CNR1KDM4EEPHX1SMN1; SMN2NPC1
Iodide SCHEMBL5681577 0.90 CNR1 (0.56) CNR1KDM4EEPHX1SMN1; SMN2NPC1
SCHEMBL5683571 0.90 CNR1 (0.61) CNR1KDM4EEPHX1SMN1; SMN2NPC1
SCHEMBL5679823 0.89 CNR1 (0.62) CNR1KDM4EEPHX1SMN1; SMN2NPC1
Iodide SCHEMBL5683619 0.86 CNR1 (0.52) CNR1KDM4EEPHX1SMN1; SMN2NPC1
SCHEMBL22834239 0.83 CNR1 (1.00) CNR1KDM4EEPHX1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200395-B1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BREWERY (JP) 2006-03-29 EP claimed
US-6875884-B1 Urea derivatives as inhibitors for CCR-3 receptor KIRIN BEER KABUSHIKI KAISHA (JP) 2005-04-05 US claimed
EP-1200395-A1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BEER KABUSHIKI KAISHA (JP) 2002-05-02 EP claimed
WO-2001009088-A1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BEER KABUSHIKI KAISHA (JP) 2001-02-08 WO claimed
EP-1200395-B1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BREWERY (JP) 2006-03-29 EP disclosed
US-6875884-B1 Urea derivatives as inhibitors for CCR-3 receptor KIRIN BEER KABUSHIKI KAISHA (JP) 2005-04-05 US disclosed
EP-1200395-A1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BEER KABUSHIKI KAISHA (JP) 2002-05-02 EP disclosed
WO-2001009088-A1 UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR KIRIN BEER KABUSHIKI KAISHA (JP) 2001-02-08 WO disclosed