Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.44 |
| ▸ | SRC | P12931 | 10/20 | 0.42 |
| ▸ | SYK | P43405 | 10/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5685172 | 0.92 | GSK3A (0.41) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5685177 | 0.89 | MAPK14 (0.47) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5681353 | 0.89 | MAPK14 (0.43) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5682451 | 0.85 | GSK3A (0.45) | GSK3ASRCSYKMAPK14CXCL8 | |
| SCHEMBL5685421 | 0.84 | GSK3A (0.44) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5685433 | 0.83 | GSK3A (0.47) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5685361 | 0.83 | MAPK14 (0.41) | GSK3ASRCSYKMAPK14CXCL8 | |
| SCHEMBL5682743 | 0.83 | GSK3A (0.37) | GSK3ASRCSYKMAPK14LCK | |
| SCHEMBL5685377 | 0.81 | MAPK14 (0.41) | GSK3ASRCSYKMAPK14CXCL8 | |
| SCHEMBL5682690 | 0.81 | GSK3A (0.47) | GSK3ASRCSYKMAPK14CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631567-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005016918-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | claimed |