Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.42 |
| ▸ | GSK3A | P49840 | 12/20 | 0.37 |
| ▸ | SRC | P12931 | 7/20 | 0.37 |
| ▸ | SYK | P43405 | 7/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5685361 | 0.92 | MAPK14 (0.41) | MAPK14GSK3ASRCSYKCXCL8 | |
| SCHEMBL5681344 | 0.90 | MAPK14 (0.42) | MAPK14GSK3ASRCSYKCXCL8 | |
| SCHEMBL5682438 | 0.89 | MAPK14 (0.44) | MAPK14GSK3ASRCSYKCXCL8 | |
| SCHEMBL5685158 | 0.87 | MAPK14 (0.42) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL5685601 | 0.87 | MAPK14 (0.52) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL5685356 | 0.86 | MAPK14 (0.49) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL5685369 | 0.85 | MAPK14 (0.40) | MAPK14GSK3ASRCSYKCXCL8 | |
| SCHEMBL5681481 | 0.85 | GSK3A (0.46) | MAPK14GSK3ASRCSYKCXCL8 | |
| SCHEMBL5682745 | 0.84 | MAPK14 (0.43) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL5685250 | 0.84 | GSK3A (0.49) | MAPK14GSK3ASRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631567-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005016918-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | claimed |