Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL8027991 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL892614 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL2763245 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL1801721 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL1136528 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL27672961 | 0.98 | SLC7A5 (0.42) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL29250210 | 0.97 | SLC7A5 (0.41) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL22769647 | 0.94 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL20678156 | 0.94 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL3967555 | 0.94 | SLC7A5 (0.39) | SLC7A5CYP3A4CYP1A2PKMALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6353 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115590014-A | Erythrocyte preservation solution and preparation method thereof | 无锡托马自然生物技术有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| EP-3946280-A1 | A DELIVERY SYSTEM COMPRISING SILICON NANOPARTICLES | Sisaf Ltd (GB) | 2022-02-09 | — | — | EP | claimed |
| CN-111035623-B | IDO1 polypeptide nano inhibitor and preparation method and application thereof | 国家纳米科学中心 | 2021-11-23 | — | — | CN | claimed |
| WO-2020193999-A1 | A DELIVERY SYSTEM COMPRISING SILICON NANOPARTICLES | SISAF LIMITED (GB) | 2020-10-01 | — | — | WO | claimed |
| CN-111035623-A | IDO1 polypeptide nano inhibitor and preparation method and application thereof | 国家纳米科学中心 | 2020-04-21 | — | — | CN | claimed |
| US-20180084811-A1 | NOVEL AND USEFUL EDIBLE SALT AND METHODS OF USE AND PRODUCTION THEREOF | E.K. SALT LTD. (IL) | 2018-03-29 | — | — | US | claimed |
| EP-3277098-A1 | NOVEL AND USEFUL EDIBLE SALT AND METHODS OF USE AND PRODUCTION THEREOF | E.k.salt Ltd. (IL) | 2018-02-07 | — | — | EP | claimed |
| CN-107427051-A | New and useful edible salt and its use and production method | E.K.盐业有限公司 | 2017-12-01 | — | — | CN | claimed |
| WO-2016157178-A1 | NOVEL AND USEFUL EDIBLE SALT AND METHODS OF USE AND PRODUCTION THEREOF | E.K.SALT LTD. (IL) | 2016-10-06 | — | — | WO | claimed |
| CN-103505729-B | A kind of stable rabies virus human antibody combination preparation | NCPC NEW DRUG RESEARCH AND DEVELOPMENT CO., LTD. (CN) | 2015-10-28 | — | — | CN | claimed |
| WO-2003104381-A2 | METHODS | ASTRAZENECA AB (SE) | 2003-12-18 | — | — | WO | claimed |
| EP-1370589-A2 | RATIONALLY DESIGNED ANTIBODIES | ALEXION PHARMACEUTICALS, INC. (US) | 2003-12-17 | — | — | EP | claimed |
| US-6562610-B1 | Transport protein for use in the treatment of cell proliferation disorders | CYTOKINETICS, INC. | 2003-05-13 | — | — | US | claimed |
| US-20030049683-A1 | Immunoglobulin for use in human therapeutics and diagnostics | ALEXION PHARMACEUTICAL, INC. | 2003-03-13 | — | — | US | claimed |
| US-6531579-B1 | Isolated native sequence vertebrate fused polypeptide; signaling and mediator proteins; Hedgehog cascade; cell proliferation, differentiation | GENENTECH, INC. | 2003-03-11 | — | — | US | claimed |
| WO-2002046238-A2 | RATIONALLY DESIGNED ANTIBODIES | ALEXION PHARMACEUTICALS, INC. (US) | 2002-06-13 | — | — | WO | claimed |
| EP-0172275-B2 | COMPOSITION SUITABLE FOR IMPARTING BUTTER AND/OR ANIMAL NOTES, AND METHOD OF MAKING SAME | FRIES & FRIES, INC. (US) | 1992-07-01 | — | — | EP | claimed |
| US-4863898-A | Amino acid chelated compositions for delivery to specific biological tissue sites | ALBION INTERNATIONAL, INC. (US) | 1989-09-05 | — | — | US | claimed |
| EP-0172275-B1 | COMPOSITION SUITABLE FOR IMPARTING BUTTER AND/OR ANIMAL NOTES, AND METHOD OF MAKING SAME | FRIES & FRIES, INC. (US) | 1989-04-19 | — | — | EP | claimed |
| EP-0172275-A1 | Composition suitable for imparting butter and/or animal notes, and method of making same | FRIES & FRIES, INC. (US) | 1986-02-26 | — | — | EP | claimed |