Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.64 |
| ▸ | JAK1 | P23458 | 3/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | STK4 | Q13043 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.53 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.53 |
| ▸ | ITK | Q08881 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492001 | 0.85 | SYK (0.62) | SYKCSF1RAURKACDK2BRD4 | |
| SCHEMBL5686069 | 0.82 | SYK (0.53) | SYKJAK3KCNH2 | |
| SCHEMBL8735645 | 0.82 | SYK (0.79) | SYKJAK1JAK3JAK2CHEK1 | |
| SCHEMBL4488495 | 0.81 | SYK (0.62) | SYKJAK2FLT3MAPK10CSF1R | |
| SCHEMBL4985685 | 0.79 | MAPT (0.59) | CHEK1MEN1MAPTKMT2ARAB9A | |
| SCHEMBL737349 | 0.79 | SYK (1.00) | SYKJAK1JAK3JAK2CHEK1 | |
| SCHEMBL4499479 | 0.78 | SYK (0.67) | SYKJAK1JAK3JAK2AURKA | |
| SCHEMBL735485 | 0.77 | SYK (0.93) | SYKJAK1JAK3JAK2CHEK1 | |
| SCHEMBL738226 | 0.76 | SYK (1.00) | SYKJAK1JAK3JAK2CHEK1 | |
| SCHEMBL29576356 | 0.76 | JAK3 (0.56) | SYKJAK1JAK3JAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |