Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.49 |
| ▸ | SIK1 | P57059 | 2/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.46 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 9/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498139 | 0.90 | LCK (0.46) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4492970 | 0.87 | SIK1 (0.51) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4488643 | 0.87 | SIK1 (0.61) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL5686156 | 0.87 | LCK (0.47) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4505318 | 0.84 | LCK (0.60) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4500525 | 0.83 | LCK (0.57) | JAK3LCKBTKTNK2SRC | |
| SCHEMBL4507356 | 0.82 | SIK1 (0.54) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4484237 | 0.82 | LCK (0.55) | JAK3LCKBTKTNK2SRC | |
| SCHEMBL4490661 | 0.82 | SIK1 (0.47) | JAK3LCKBTKTNK2SIK1 | |
| SCHEMBL4497579 | 0.82 | JAK3 (0.67) | JAK3LCKBTKTNK2SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |