Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | SIK1 | P57059 | 2/20 | 0.42 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.42 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5687458 | 0.90 | JAK2 (0.53) | JAK2SIK1SIK2SIK3PAK1 | |
| SCHEMBL5686238 | 0.82 | PRKCQ (0.40) | JAK2LCKKDRMAPK14SRC | |
| SCHEMBL4499210 | 0.80 | SIK1 (0.56) | SIK1SIK2SIK3BRD4JAK1 | |
| SCHEMBL4491720 | 0.79 | SIK1 (0.56) | JAK2SIK1SIK2SIK3PAK1 | |
| SCHEMBL5686735 | 0.79 | LCK (0.53) | LCKKDRMAPK14SRCJAK3 | |
| SCHEMBL4557888 | 0.79 | KDR (0.53) | LCKKDRMAPK14SRCEGFR | |
| SCHEMBL4560194 | 0.79 | LCK (0.58) | JAK2LCKKDRMAPK14SRC | |
| SCHEMBL5689524 | 0.77 | KDR (0.43) | JAK2LCKKDRMAPK14SRC | |
| SCHEMBL4565001 | 0.75 | SYK (0.46) | JAK2PAK1LCKKDRSRC | |
| SCHEMBL5686618 | 0.75 | LCK (0.48) | JAK2LCKKDRMAPK14SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |