Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 2/20 | 0.48 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.48 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509255 | 0.93 | SIK1 (0.51) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4496744 | 0.91 | SIK1 (0.49) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4495399 | 0.91 | SIK1 (0.48) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4497691 | 0.88 | SIK1 (0.49) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL5689566 | 0.88 | TNK2 (0.46) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4502497 | 0.87 | SIK1 (0.48) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4501384 | 0.86 | SIK1 (0.52) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL5689749 | 0.86 | SIK1 (0.43) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL5686330 | 0.85 | TNK2 (0.45) | SIK1SIK2SIK3JAK3TNK2 | |
| SCHEMBL4495398 | 0.85 | SIK1 (0.49) | SIK1SIK2SIK3JAK3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | claimed |
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |