Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.69 |
| ▸ | BTK | Q06187 | 1/20 | 0.69 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.69 |
| ▸ | SRC | P12931 | 8/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493578 | 0.93 | LCK (0.72) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5688959 | 0.92 | LCK (0.71) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5689444 | 0.92 | LCK (0.81) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5689194 | 0.92 | LCK (0.72) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5686215 | 0.91 | JAK3 (0.66) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5686211 | 0.90 | LCK (0.68) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5689018 | 0.90 | LCK (0.70) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5686287 | 0.90 | LCK (0.65) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4495494 | 0.89 | LCK (0.69) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5689367 | 0.89 | JAK3 (0.65) | LCKJAK3BTKTNK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |