Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 8/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | SIK1 | P57059 | 2/20 | 0.44 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.44 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487526 | 0.95 | LCK (0.47) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5686224 | 0.95 | TNK2 (0.47) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5686564 | 0.93 | LCK (0.48) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4496582 | 0.91 | SIK1 (0.46) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4490736 | 0.90 | SIK1 (0.49) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4485113 | 0.90 | TNK2 (0.49) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4496586 | 0.90 | SRC (0.46) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL5689363 | 0.90 | TNK2 (0.45) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4506876 | 0.90 | SIK1 (0.48) | LCKJAK3BTKTNK2SRC | |
| SCHEMBL4497850 | 0.90 | JAK3 (0.48) | LCKJAK3BTKTNK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | claimed |