Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.67 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | SIK1 | P57059 | 2/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499920 | 0.93 | BTK (0.70) | BTKTNK2LCKJAK3STAT6 | |
| SCHEMBL4484038 | 0.92 | JAK3 (0.62) | BTKTNK2LCKJAK3STAT6 | |
| SCHEMBL4500759 | 0.90 | BTK (0.67) | BTKTNK2LCKJAK3STAT6 | |
| SCHEMBL5689444 | 0.88 | LCK (0.81) | BTKTNK2LCKJAK3SRC | |
| SCHEMBL5686089 | 0.87 | BTK (0.51) | BTKTNK2LCKJAK3STAT6 | |
| SCHEMBL4506260 | 0.84 | LCK (0.69) | BTKTNK2LCKJAK3SRC | |
| SCHEMBL5689194 | 0.83 | LCK (0.72) | BTKTNK2LCKJAK3SRC | |
| SCHEMBL4501630 | 0.83 | JAK3 (0.68) | BTKTNK2LCKJAK3JAK2 | |
| SCHEMBL4504109 | 0.82 | LCK (0.84) | BTKTNK2LCKJAK3SRC | |
| SCHEMBL4486459 | 0.82 | LCK (0.78) | BTKTNK2LCKJAK3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |