Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | LCK | P06239 | 6/20 | 0.53 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.51 |
| ▸ | QPCT | Q16769 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496504 | 0.86 | KDR (0.52) | KDRLCKSRCMAPK14EGFR | |
| SCHEMBL4501652 | 0.85 | LCK (0.57) | KDRLCKSRCMCHR1QPCT | |
| SCHEMBL4504797 | 0.84 | PAK1 (0.57) | KDRLCKSRCMAPK14EGFR | |
| SCHEMBL4504378 | 0.84 | LCK (0.52) | KDRLCKSRCMCHR1QPCT | |
| SCHEMBL5686145 | 0.83 | TNK2 (0.50) | KDRLCKSRCMAPK14EGFR | |
| SCHEMBL4497254 | 0.83 | LCK (0.53) | KDRLCKSRCQPCTMAPK14 | |
| SCHEMBL5686260 | 0.82 | KDR (0.49) | KDRLCKSRCMAPK14EGFR | |
| SCHEMBL4508592 | 0.81 | LCK (0.56) | KDRLCKSRCMAPK14EGFR | |
| SCHEMBL4496785 | 0.80 | KDR (0.52) | KDRLCKSRCMCHR1MAPK14 | |
| SCHEMBL4509912 | 0.80 | LCK (0.55) | KDRLCKSRCMAPK14EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |