SCHEMBL5689408

SCHEMBL5689408

COc1cccc(-c2cccc(C(O)(c3c[nH]cn3)C(C)C)c2)c1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 11/20 0.54
CYP17A1 P05093 9/20 0.54
DYRK1A Q13627 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HDAC4 P56524 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
XDH P47989 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688348 0.92 CYP17A1 (0.64) CYP3A4CYP17A1CYP2C9CYP2C19HDAC4
SCHEMBL5690859 0.92 CYP17A1 (0.50) CYP3A4CYP17A1DYRK1ACLK4XDH
SCHEMBL5690534 0.87 CYP17A1 (0.60) CYP3A4CYP17A1
SCHEMBL5690890 0.84 CYP17A1 (0.44) CYP3A4CYP17A1CYP2C9CYP2C19
SCHEMBL5688934 0.83 CYP17A1 (0.52) CYP3A4CYP17A1
SCHEMBL5688702 0.83 CYP17A1 (0.53) CYP3A4CYP17A1
SCHEMBL5688356 0.83 CYP17A1 (0.50) CYP3A4CYP17A1
SCHEMBL5688968 0.83 PTPN5 (0.46) CYP3A4CYP17A1CYP2C9CYP2C19
SCHEMBL5688515 0.82 CYP17A1 (0.63) CYP3A4CYP17A1
SCHEMBL5691340 0.82 CYP17A1 (0.63) CYP3A4CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed