Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | DGKA | P23743 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936889 | 1.00 | TSHR (0.73) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL30572458 | 0.99 | TSHR (0.71) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL30578396 | 0.99 | TSHR (0.71) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL28060401 | 0.94 | TSHR (0.82) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL19025389 | 0.94 | TSHR (0.82) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL9934514 | 0.94 | TSHR (0.82) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL7721991 | 0.94 | TSHR (0.82) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL30387910 | 0.93 | TSHR (0.79) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL8569244 | 0.93 | TSHR (0.84) | TSHRCYP3A4ATMTDP1MAPT | |
| SCHEMBL13571597 | 0.92 | TSHR (0.82) | TSHRCYP3A4ATMTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654197-A1 | CARRIER BASED ON GRANULES PRODUCED FROM PYROGENICALLY PREPARED SILICON DIOXIDES | Degussa AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016823-A1 | CARRIER BASED ON GRANULES PRODUCED FROM PYROGENICALLY PREPARED SILICON DIOXIDES | DEGUSSA AG (DE) | 2005-02-24 | — | — | WO | disclosed |