Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.48 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | KDM1A | O60341 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690064 | 1.00 | KDM4E (0.49) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5690073 | 1.00 | KDM4E (0.49) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5690102 | 0.87 | KDM4E (0.47) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5689745 | 0.87 | KDM4E (0.47) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5689751 | 0.87 | KDM4E (0.47) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5689738 | 0.87 | KDM4E (0.47) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 | |
| SCHEMBL5691903 | 0.86 | MRGPRX4 (0.46) | KMT2ASMN1; SMN2LIPGMRGPRX4MAOA | |
| SCHEMBL5689684 | 0.85 | GRIN2B (0.45) | KDM4ESMN1; SMN2CYP2C9GRIN1GRIN2B | |
| SCHEMBL5689681 | 0.85 | GRIN2B (0.45) | KDM4ESMN1; SMN2CYP2C9GRIN1GRIN2B | |
| SCHEMBL5690088 | 0.82 | FOXM1 (0.55) | KDM4EKMT2ASMN1; SMN2LIPGFOXM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982026-B1 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | EP | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |