Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.44 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690277 | 1.00 | KDM4E (0.52) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5689661 | 0.87 | KDM4E (0.52) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL7023319 | 0.87 | KDM4E (0.52) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5689666 | 0.87 | KDM4E (0.52) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5691626 | 0.83 | BCHE (0.49) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5691624 | 0.83 | BCHE (0.49) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5689914 | 0.82 | KDM4E (0.47) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL5689912 | 0.82 | KDM4E (0.47) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL6841392 | 0.82 | KDM4E (0.56) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 | |
| SCHEMBL6836225 | 0.82 | KDM4E (0.56) | KDM4EGRIN2BGRIN1SPHK1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982026-B1 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | EP | disclosed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |