Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23408969 | 0.88 | PDPK1 (0.54) | TRPV1TRPV4PDPK1CA12CA1 | |
| SCHEMBL4792781 | 0.83 | TRPV1 (0.45) | TRPV1TRPV4CA12CA1CA2 | |
| SCHEMBL11910662 | 0.82 | CA12 (0.60) | TRPV1TRPV4CA12CA1CA2 | |
| SCHEMBL11888082 | 0.81 | GRIN2B (0.46) | TRPV1TRPV4KDM1A | |
| SCHEMBL1169931 | 0.81 | TRPV1 (0.53) | TRPV1TRPV4CA12CA1CA2 | |
| SCHEMBL1169928 | 0.81 | TRPV1 (0.53) | TRPV1TRPV4CA12CA1CA2 | |
| SCHEMBL1858738 | 0.80 | GAA (0.42) | TRPV1TRPV4PDPK1LMNA | |
| SCHEMBL1858736 | 0.80 | GAA (0.42) | TRPV1TRPV4PDPK1LMNA | |
| SCHEMBL1858737 | 0.80 | GAA (0.42) | TRPV1TRPV4PDPK1LMNA | |
| SCHEMBL11997977 | 0.79 | TRPV1 (0.58) | TRPV1TRPV4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658269-A1 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2004111009-A1 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2004-12-23 | — | — | WO | disclosed |