Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 8/20 | 0.57 |
| ▸ | PRNP | P04156 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | DCAF1 | Q9Y4B6 | 3/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.47 |
| ▸ | MMP12 | P39900 | 3/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5927019 | 0.88 | CTSA (0.56) | CTSACYP26A1MMP12SUCNR1MMP3 | |
| SCHEMBL4827815 | 0.82 | DCAF1 (0.54) | CTSAPRNPNPSR1RXFP1DCAF1 | |
| SCHEMBL5692210 | 0.81 | ITGB1 (0.56) | — | |
| SCHEMBL3994930 | 0.81 | CTSA (0.57) | CTSADCAF1MMP12SUCNR1 | |
| SCHEMBL5927213 | 0.81 | CTSA (0.52) | CTSANPSR1RXFP1CYP26A1 | |
| SCHEMBL5926784 | 0.79 | CTSA (0.60) | CTSACYP26A1MMP12MMP3MMP9 | |
| SCHEMBL3992014 | 0.78 | SERPINE1 (0.50) | CTSANPSR1RXFP1DCAF1MMP12 | |
| SCHEMBL5927034 | 0.78 | DCAF1 (0.52) | CTSANPSR1RXFP1DCAF1SUCNR1 | |
| SCHEMBL5927285 | 0.78 | CTSA (0.56) | CTSACYP26A1SUCNR1 | |
| SCHEMBL5926505 | 0.77 | CTSA (0.60) | CTSADCAF1SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660439-A2 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-05-31 | — | — | EP | claimed |
| WO-2005014533-A2 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-02-17 | — | — | WO | claimed |