Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296990 | 1.00 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| Hydrochloric Acid SCHEMBL5840423 | 0.99 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| Hydrochloric Acid SCHEMBL5780480 | 0.99 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| Hydrochloric Acid SCHEMBL5780483 | 0.99 | PDE4B (0.54) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| SCHEMBL5840169 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| SCHEMBL8313084 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL5780660 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| SCHEMBL5780663 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4PTGER4 | |
| SCHEMBL5840683 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL5840694 | 0.92 | PDE4B (0.55) | PDE4BPDE4APDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651647-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDEA4 INHIBITORS | Pfizer Limited (GB) | 2006-05-03 | — | — | EP | claimed |
| WO-2005010001-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDEA4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | claimed |
| EP-1651647-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDEA4 INHIBITORS | Pfizer Limited (GB) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005010001-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDEA4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |