SCHEMBL569370

SCHEMBL569370

CC(CO)[C@@H](C)Nc1nc(Nc2ccc(C(=O)O)c(Cl)c2)c2ncn(C(C)C)c2n1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 13/20 0.81
CDK5R1 Q15078 13/20 0.81
CDK1 P06493 8/20 0.81
CCNA2 P20248 8/20 0.81
CDK2 P24941 8/20 0.81
CCNA1 P78396 8/20 0.81
KDM4E B2RXH2 6/20 0.81
CCNB1 P14635 4/20 0.81
CCNB2 O95067 3/20 0.81
ALDH1A1 P00352 3/20 0.81
CCNB3 Q8WWL7 3/20 0.81
CCNE2 O96020 2/20 0.81
INSR P06213 2/20 0.81
PRKACA P17612 2/20 0.81
PRKACG P22612 2/20 0.81
PRKACB P22694 2/20 0.81
CCNE1 P24864 2/20 0.81
MAPK3 P27361 2/20 0.81
NTRK1 P04629 1/20 0.81
NTRK2 Q16620 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14845886 0.91 CDK5 (0.84) CDK5CDK5R1CDK1CCNA2CDK2
Purvalanol B SCHEMBL23509845 0.90 CDK5 (1.00) CDK5CDK5R1CDK1CCNA2CDK2
Purvalanol B SCHEMBL6932922 0.90 CDK5 (1.00) CDK5CDK5R1CDK1CCNA2CDK2
Purvalanol B SCHEMBL29546074 0.90 CDK5 (1.00) CDK5CDK5R1CDK1CCNA2CDK2
Purvalanol B SCHEMBL27951 0.90 CDK5 (1.00) CDK5CDK5R1CDK1CCNA2CDK2
SCHEMBL13498146 0.83 CDK5 (0.87) CDK5CDK5R1CDK1CCNA2CDK2
SCHEMBL1325062 0.82 CDK5 (0.70) CDK5CDK5R1CDK1CCNA2CDK2
SCHEMBL6934099 0.82 CDK5 (0.70) CDK5CDK5R1CDK1CCNA2CDK2
SCHEMBL569369 0.82 CDK5 (0.70) CDK5CDK5R1CDK1CCNA2CDK2
SCHEMBL13497847 0.82 CDK5 (0.86) CDK5CDK5R1CDK1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2600862-A2 INHIBITORS OF ERK FOR DEVELOPMENTAL DISORDERS OF NEURONAL CONNECTIVITY Case Western Reserve University (US) 2013-06-12 EP claimed
WO-2012019113-A2 INHIBITORS OF ERK FOR DEVELOPMENTAL DISORDERS OF NEURONAL CONNECTIVITY CASE WESTERN RESERVE UNIVERSITY (US) 2012-02-09 WO claimed
EP-2600862-A2 INHIBITORS OF ERK FOR DEVELOPMENTAL DISORDERS OF NEURONAL CONNECTIVITY Case Western Reserve University (US) 2013-06-12 EP disclosed
WO-2012019113-A2 INHIBITORS OF ERK FOR DEVELOPMENTAL DISORDERS OF NEURONAL CONNECTIVITY CASE WESTERN RESERVE UNIVERSITY (US) 2012-02-09 WO disclosed