Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CD38 | P28907 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739239 | 0.85 | CDC7 (0.48) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL6131490 | 0.85 | GSK3B (0.48) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL7732439 | 0.80 | KDR (0.55) | ROCK2CLK4GSK3BMKNK2CSF1R | |
| SCHEMBL7737558 | 0.80 | KDR (0.47) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL7460271 | 0.80 | CDC7 (0.46) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL7738450 | 0.79 | RET (0.55) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL6680013 | 0.77 | CDC7 (0.40) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| Hydrochloric Acid SCHEMBL9960799 | 0.75 | CDC7 (0.46) | ROCK2MAP4K4CLK4CDC7GSK3B | |
| SCHEMBL7739127 | 0.75 | RPS6KB1 (0.50) | CSF1RCD38RPS6KB1ABL1FLT1 | |
| SCHEMBL7739113 | 0.73 | CDC7 (0.43) | ROCK2MAP4K4CLK4CDC7GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667721-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | Novartis AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027973-A2 | COMBINATIONS OF A VEGF RECEPTOR INHIBITOR WITH OTHER THERAPEUTIC AGENTS | NOVARTIS AG (CH) | 2005-03-31 | — | — | WO | disclosed |