SCHEMBL5694641

SCHEMBL5694641

C=C(C(=O)c1ccc(C=CC(=O)O)cc1)c1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
MAOB P27338 7/20 0.51
CYP1B1 Q16678 1/20 0.51
CXCL12 P48061 1/20 0.50
MAOA P21397 3/20 0.49
HCAR2 Q8TDS4 2/20 0.47
CA12 O43570 1/20 0.47
AKR1B10 O60218 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
ESR1 P03372 1/20 0.47
CA3 P07451 1/20 0.47
PKM P14618 1/20 0.47
TYR P14679 1/20 0.47
AKR1B1 P15121 1/20 0.47
CA4 P22748 1/20 0.47
CA6 P23280 1/20 0.47
DPP4 P27487 1/20 0.47
CA5A P35218 1/20 0.47
CA7 P43166 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5694639 1.00 CYP1A2 (0.51) CYP1A2MAOBCYP1B1CXCL12MAOA
SCHEMBL4407258 0.87 HDAC3 (0.58) MAOBCYP1B1HCAR2CA12AKR1B10
SCHEMBL4407256 0.87 HDAC3 (0.58) MAOBCYP1B1HCAR2CA12AKR1B10
SCHEMBL5694796 0.84 MAPT (0.56) MAOBCYP1B1MAOAHCAR2CA12
SCHEMBL5694646 0.84 TNFRSF1A (0.56) MAOBCYP1B1MAOAHCAR2CA12
SCHEMBL5694798 0.84 MAPT (0.56) MAOBCYP1B1MAOAHCAR2CA12
SCHEMBL5694645 0.84 TNFRSF1A (0.56) MAOBCYP1B1MAOAHCAR2CA12
SCHEMBL5694655 0.83 HDAC2 (0.53) CYP1A2CYP1B1HCAR2CA12AKR1B10
SCHEMBL5694657 0.83 HDAC2 (0.53) CYP1A2CYP1B1HCAR2CA12AKR1B10
SCHEMBL126171 0.83 CYP1A2 (0.72) CYP1A2MAOBCYP1B1CXCL12MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1094055-B1 NOVEL VINYLBENZENE DERIVATIVES SANTEN PHARMACEUTICAL CO LTD (JP) 2006-04-26 EP disclosed
US-6329547-B1 USEFUL AS THERAPEUTIC AGENTS FOR GLAUCOMA SANTEN PHARMACEUTICAL CO., LTD. (JP) 2001-12-11 US disclosed
EP-1094055-A1 NOVEL VINYLBENZENE DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 2001-04-25 EP disclosed